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siRNA Synthesis (Inquire for Pricing)
 
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siRNA Synthesis

RNAi (RNA interference) is a phenomenon in which small double-stranded RNA (referred to as small interference RNA or siRNA) knocks down the expression of its corresponding gene. RNAi has been observed in plants, C. elegans and Drosophila, for a number of years. It was only until recently that RNAi was discovered to work in mammalian systems.

Small interference RNA (siRNA) is 19-22 nt double-stranded RNA. It works by cleaving and destroying its cognate RNA. siRNA first assembles into RNA-induced silencing complexes (RISCs), and it then activates the complex by unwinding its RNA strands. The unwound RNA strands subsequently guide the complex to the complementary RNA molecules, where the complex cleaves and destroys the cognate RNA, thus resulting in the RNAi phenomenon.

RNAi has evolved into a powerful tool to study gene function. Here are some of its applications:

A stable cell line with a specific gene knocked-out can be established. Its phenotype can be studied.

A knock-out mouse line can be established using transgenic siRNA method.

siRNA can be put into a vector with an inducible promoter to study its effect.

siRNA can be delivered by using viral vector and used for gene therapy purpose.

siRNA can be mimicked by chemical molecule and used for drug development.


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